Authors: ShaoGuang Liao Lu Liu Ying Wang YingYi Zhang YaJie Wang
Publish Date: 2012/05/29
Volume: 138, Issue: 10, Pages: 1689-1695
Abstract
The association between Asp312Asn and Lys751Gln polymorphisms of Xeroderma pigmentosum Group D XPD and prostate cancer risk are still inconclusive For better understanding of the effects of these two polymorphisms on prostate cancer risk a metaanalysis was performedAn extensive search was performed to identify all case–control studies investigating such association The strength of association between these two polymorphisms and prostate cancer risk was assessed by odds ratio OR with the corresponding 95 confidence interval 95 CIA total of seven case–control studies were identified among which five studies 1257 cases and 1956 controls were eligible for Asp312Asn polymorphism and six studies 1451 cases and 2375 controls were eligible for Lys751Gln polymorphism Asp312Asn polymorphism was associated with an increased risk of prostate cancer in additive and recessive genetic models additive model OR = 168 95 CI = 128–222 P = 000 recessive model OR = 165 95 CI = 127–215 P = 000 In the subgroup analysis Asp312Asn polymorphism was associated with an increased risk of prostate cancer among Asians in all three genetic models additive model OR = 209 95 CI = 139–314 P = 000 dominant model OR = 149 95 CI = 112–198 P = 001 recessive model OR = 193 95 CI = 131–283 P = 000 However no significant associations were found between Lys751Gln polymorphism and prostate cancer risk in the overall analyses or the subgroup analyses by ethnicity
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