Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: J Cancer Res Clin Oncol

Search In Journal Title:

Abbravation: Journal of Cancer Research and Clinical Oncology

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1007/bf02164809

Search In DOI:

ISSN

1432-1335

Search In ISSN:
Search In Title Of Papers:

Dihydroartemisinin enhances radiosensitivity of hu

Authors: S J Kim M S Kim J W Lee C H Lee H Yoo S H Shin M J Park S H Lee
Publish Date: 2005/11/05
Volume: 132, Issue: 2, Pages: 129-135
PDF Link

Abstract

Purpose The antimalarial agent artemisinin also confers cancerspecific cytotoxic effects by reacting with ferrous iron atoms to form free radicals Here we investigated the radiosensitizing effects of dihydroartemisinin on glioma cells and assessed some possible mechanisms for these effects Materials and methods U373MG glioma cells treated with various concentrations of dihydroartemisinin plus radiation and efficiency of radiosensitization was assessed by clonogenic survival assay Expression and activity of antioxidant enzymes glutathioneStransferase GST were quantified by western blot and enzymatic activity analyses respectively Results Dihydroartemisinin showed higher cytotoxicity in the glioma cell lines than in the liver breast or cervical cancer cell lines In clonogenic survival assays treatment with dihydroartemisinin alone dosedependently reduced the number of U373MG colonies while treatment with dihydroartemisinin plus γirradiation showed far lower clonal survival than cultures treated with radiation or dihydroartemisinin alone The radiosensitizing effect of dihydroartemisinin was blocked significantly by the free radical scavengers NAC and TIRON indicating association with dihydroartemisinininduced ROS generation In addition the radiationinduced expression of endogenous GST was suppressed by treatment with dihydroartemisinin The radiosensitizing effect of dihydroartemisinin was also markedly enhanced by the addition of holotransferrin Conclusion Taken together our results strongly suggest that dihydroartemisinin triggers production of ROS and inhibits GST activity leading to effective and therapeutically relevant radiosensitization of human glioma cells

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Enhancement of dendritic cell-tumor fusion vaccine potency by indoleamine-pyrrole 2,3-dioxygenase inhibitor, 1-MT
  2. Impact of denosumab use on the survival of untreated non-squamous non-small cell lung cancer patients with bone metastases
  3. The clinical relevance and prognostic significance of adenosine triphosphate ATP-binding cassette (ABCB5) and multidrug resistance (MDR1) genes expression in acute leukemia: an Egyptian study
  4. Salvage therapy with topotecan in heavily pretreated ovarian cancer patients
  5. Resveratrol plays dual roles in pancreatic cancer cells
  6. Twenty-year survivors after resection for hepatocellular carcinoma-analysis of 53 cases
  7. Local delivery of slow-releasing temozolomide microspheres inhibits intracranial xenograft glioma growth
  8. Colour junctions as predictors of radiosensitivity: X-irradiation combined with gemcitabine in a lung carcinoma cell line
  9. Up-regulation of microRNA-155 promotes cancer cell invasion and predicts poor survival of hepatocellular carcinoma following liver transplantation
  10. Oblimersen and α-interferon in metastatic renal cancer: a phase II study of the California Cancer Consortium
  11. Interstitial growth as an aggressive growth pattern in primary lung cancer
  12. Effect of the cyclin-dependent kinases inhibitor p27 on resistance of ovarian cancer multicellular spheroids to anticancer chemotherapy
  13. Preoperative NLR for predicting survival rate after radical resection combined with adjuvant immunotherapy with CIK and postoperative chemotherapy in gastric cancer
  14. Prostate transitional zone volume-based nomogram for predicting prostate cancer and high progression prostate cancer in a real-world population
  15. Imbalance in redox status is associated with tumor aggressiveness and poor outcome in lung adenocarcinoma patients
  16. A C118T polymorphism of ERCC1 and response to cisplatin chemotherapy in patients with late-stage non-small cell lung cancer
  17. Genetic polymorphism of ESR1 rs2881766 increases breast cancer risk in Korean women
  18. Sodium valproate, a histone deacetylase inhibitor, decreases the secretion of soluble Fas by human osteosarcoma cells and increases their sensitivity to Fas-mediated cell death
  19. Elevated risk of colorectal cancer associated with the AA genotype of the cyclin D1 A870G polymorphism in an Indian population
  20. CD133 expression in renal cell carcinoma (RCC) is correlated with nuclear hypoxia-inducing factor 1α (HIF-1α)
  21. Surgical debulking of gastrointestinal stromal tumors: Is it a reasonable option after second-line treatment with sunitinib?
  22. Changes in [18F]Fluoro-2-deoxy- d -glucose incorporation induced by doxorubicin and anti-HER antibodies by breast cancer cells modulated by co-treatment with metformin and its effects on intracellular signalling
  23. Expression profiling of receptor tyrosine kinases in high-grade neuroendocrine carcinoma of the lung: a comparative analysis with adenocarcinoma and squamous cell carcinoma
  24. Serum levels of nicotinamide N -methyltransferase in patients with lung cancer
  25. XPD Asp312Asn polymorphism is a risk factor for prostate cancer
  26. Correlation of bFGF expression in renal cell cancer with clinical and histopathological features by tissue microarray analysis and measurement of serum levels
  27. Angiopoietin-2 inhibition using siRNA or the peptide antagonist L1–10 results in antitumor activity in human neuroblastoma
  28. Influence of tumor volume on survival in patients with oral squamous cell carcinoma
  29. Gefitinib (‘IRESSA’, ZD1839) inhibits EGF-induced invasion in prostate cancer cells by suppressing PI3 K/AKT activation
  30. High-dose radiotherapy with helical tomotherapy and long-term androgen deprivation therapy for prostate cancer: 5-year outcomes
  31. Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells
  32. miR-129-3p, as a diagnostic and prognostic biomarker for renal cell carcinoma, attenuates cell migration and invasion via downregulating multiple metastasis-related genes
  33. High KIT and PDGFRA are associated with shorter patients survival in gastroenteropancreatic neuroendocrine tumors, but mutations are a rare event
  34. The potential of plasma thrombomodulin as a biomarker of portal vein tumor thrombus in hepatocellular carcinoma
  35. RETRACTED ARTICLE: The prognostic relevance of node metastases in optimally cytoreduced advanced ovarian cancer
  36. PTEN immunohistochemical expression is suppressed in G1 endometrioid adenocarcinoma of the uterine corpus
  37. Isolation and comparison of mesenchymal stem-like cells from human gastric cancer and adjacent non-cancerous tissues
  38. Zur onkologischen Stellung der sogenannten „verkalkten Epitheliome“ der Haut
  39. Solute carrier protein family may involve in radiation-induced radioresistance of non-small cell lung cancer
  40. Analysis of EGF +61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy
  41. Clonal heterogeneity in osteogenic potential of lung cancer-associated fibroblasts: promotional effect of osteogenic progenitor cells on cancer cell migration
  42. Association between survivin -31G>C polymorphism and cancer risk: meta-analysis of 29 studies
  43. Cryopreserved NK cells in the treatment of haematological malignancies: preclinical study
  44. Outcome and toxicity profiles in the treatment of locally advanced lung cancer with volumetric modulated arc therapy
  45. Interferon alpha 2a downregulates VEGF expression through PI3 kinase and MAP kinase signaling pathways
  46. Identification of HTA as a novel-specific marker for human hepatocellular carcinoma
  47. Biweekly CHOP or THP-COP regimens in the treatment of newly diagnosed aggressive non-Hodgkin’s lymphoma
  48. The effectiveness of radiotherapy for leukemia cutis
  49. Bendamustine, but not fludarabine, exhibits a low stem cell toxicity in vitro
  50. Allelic loss of 14q32 in the pathogenesis of gastrointestinal and ampullary malignancies: mapping of the target region to a 17 cM interval
Search Result: