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Title of Journal: J Cancer Res Clin Oncol

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Abbravation: Journal of Cancer Research and Clinical Oncology

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Springer-Verlag

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DOI

10.1007/bf00643686

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1432-1335

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Analysis of Emphasis Type="Italic"EGF/Emphasis

Authors: Francisco das Chagas Abreu da Silveira Bruno de Almeida Lopes Clovis Orlando da Fonseca Thereza QuiricoSantos Izabel Christina Nunes de Palmer Paixão Lidia Maria da Fonte de Amorim
Publish Date: 2012/04/06
Volume: 138, Issue: 8, Pages: 1347-1354
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Abstract

Malignant gliomas are associated with alteration in EGF/EGFR signaling Functional EGF+61AG polymorphism is implicated with risk recurrence and progression of glioma This study aimed to establish a putative association of EGF+61AG with risk of glioma development production of angiogenic growth factor EGF and the response to perillyl alcohol administered by intranasal routeThe study included 83 patients with recurrent glioma enrolled in Phase I/II trial for intranasal perillyl alcohol therapy and subjects without cancer n = 196 as control group DNA was extracted from blood samples EGF genotype performed with PCR–RFLP assay and EGF circulating levels by enzyme immunoassay Adequate statistical tests were performed to verify associations between polymorphism and glioma risk and genotype correlation with EGF circulating levels The logrank test was also used to evaluate differences on patient survivalPatients with primary glioblastoma had high frequency of AA genotype p = 0037 and A allele p = 0037 Increased EGF circulating levels were observed in glioma patients with AA p = 0042 AG p = 0006 and AA + AG p = 0008 genotypes compared with GG Patients with GG genotype showed increased but not significant p  005 survival rate and EGF levels lower than 250 pg/mL was consistently p = 00374 associated with increased survivalPresence of EGF+61AG polymorphism in Brazilian subjects was associated with glioma risk and increased circulating EGF levels Better response to perillyl alcoholbased therapy was observed in a group of adult Brazilian subjects with lower EGF levelsThis study was supported in part by grants from The Rio de Janeiro Research Foundation FAPERJ grants E26/171346/20006 Conselho Nacional de Pesquisa CNPq grants 401943/20100 and 481059/20113 and Programa de Fomento à pesquisa na UFF FOPESQ 2009 and 2010

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