Authors: Jing Jiang Jingweng Wang Sadao Suzuki Vendhan Gajalakshmi Kiyonori Kuriki Yang Zhao Seiichi Nakamura Susumu Akasaka Hideki Ishikawa Shinkan Tokudome
Publish Date: 2005/12/03
Volume: 132, Issue: 3, Pages: 193-199
Abstract
Purpose To investigate whether the common cyclin D1 CCND1 A870G polymorphism is a risk factor for colorectal cancer CRC in an Indian population Methods In this study 301 newly diagnosed CRC patients and 291 healthy control subjects were genotyped by the PCRRFLP method Genotype frequencies were compared between cases and controls and the association of genotypes with CRC was studied Results The CCND1 870 A allele was more frequently observed in CRC patients than controls 063 vs 056 P=001 and after adjustment for age sex smoking habits family history family income and the consumption of meat fish vegetables and fruit an increased risk was observed for the AA genotype compared to the GG+AG genotype OR=156 95 CI 110–221 The increased risk were also found for colon OR=196 95 CI 108–357 and rectal cancer OR=151 95 CI 104–219 No correlation was observed between genotypes and age of diagnosis of CRC 499 487 and 494 years for the GG AG and AA genotypes respectively P=084 Multivariate analysis also revealed a stronger positive association with the AA genotype among patients with high meat intake OR=267 95 CI 129–551 and particularly significant inverse associations with the GG+AG genotypes were also found for those with high vegetable consumption OR=046 95 CI 027–079 of 2–3 servings/day and OR=031 95 CI 018–053 for 3 servings/day and fish intake OR=048 95 CI 028–082 Conclusion These data support the hypothesis that the CCND1 A870G polymorphism may increase the risk of CRC in our Indian populationThis work was supported in part by the International Scientific Research Program Special Cancer Research of the Japanese Ministry of Education Culture Sports Science and Technology We thank Drs V Shanta and T Rajkumar at the Cancer Institute Chennai India for their cooperation
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