Authors: Qin Qin Chi Zhang Hongcheng Zhu Xi Yang Liping Xu Jia Liu Jing Lu Liangliang Zhan Hongyan Cheng Xinchen Sun
Publish Date: 2013/09/28
Volume: 140, Issue: 2, Pages: 179-188
Abstract
A growing body of evidence has shown the possible relevance of survivin 31GC rs9904341 promoter polymorphism to the genetic susceptibility of cancer Because of the lack of available conclusive data we performed a metaanalysis of all relevant available studies to derive a more precise estimation of the relationshipA comprehensive literature search of Medline electronic database was conducted to collect relevant studies until August 18 2013 References of the retrieved articles were also screened The extracted data were statistically analyzed and pooled odds ratios ORs with 95 confidence intervals CIs were calculated to estimate the association strength using Stata version 112 softwareA total of 29 studies with 7473 cancer cases and 9086 controls were included in the metaanalysis Overall the pooled analysis revealed that suvivin 31GC polymorphism was significantly associated with increased cancer risk under multiple genetic models CC vs GG OR = 137 95 CI 106–176 CC vs CG OR = 127 95 CI = 110–146 CC vs CG + GG OR = 131 95 CI = 110–157 In subgroup analysis with different cancer types the 31GC polymorphism significantly increased the risk of colorectal gastric and urothelial cancers while this SNP remarkably decreased the susceptibility to hepatocellular carcinoma Further stratification analysis by ethnicity showed an increasing cancer risk in the Asian population CC vs GG OR = 161 95 CI 117–221 CC vs CG OR = 131 95 CI 112–153 CC vs CG + GG OR = 143 95 CI 116–177 but not in Europeans
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