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Title of Journal: J Cancer Res Clin Oncol

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Abbravation: Journal of Cancer Research and Clinical Oncology

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Springer-Verlag

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DOI

10.1007/s11618-013-0374-4

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1432-1335

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Angiopoietin2 inhibition using siRNA or the pepti

Authors: Saritha Sandra D’Souza Karine ScherzingerLaude Marc Simon Bharathi P Salimath Jochen Rössler
Publish Date: 2012/07/10
Volume: 138, Issue: 12, Pages: 2017-2026
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Abstract

Angiopoietin2 downregulation by siRNA or shRNA was evaluated in vitro in Kelly cells Angiopoietin2 shRNAtransfected Kelly cells were tested in a chorioallantoic membrane CAM assay to evaluate tumor growth and microvessel density The effects of L1–10 a peptide–Fc fusion molecule blocking angiopoietin2/Tie2 interaction administered 3 times/week were assessed in a murine neuroblastoma xenograft modelAngiopoietin2 downregulation by siRNA or shRNA in Kelly cells inhibited cell proliferation and migration In vivo growth and microvessel density of angiopoietin2 shRNAtransfected Kelly cells in the CAM assay were reduced Therapy of advanced tumors with L1–10 did not stop tumor progression However starting L1–10 treatment at the same time as neuroblastoma cell injection significantly inhibited tumor growth vehicule 903 ± 160 mm3 L1–10 270 ± 152 mm3 after 26 days P  005 Microvessel density was reduced in both L1–10treated tumors whereas expression of angiopoietin2 and VEGFA did not changeWe would like to thank Peter Nöllke for assistance in statistics and Christiane OlkBatz and Nora Fischer for assistance in qPCR The work was supported by a grant of the Wissenschaftliche Gesellschaft Freiburg Saritha S D’Souza received a shortterm scholarship of the Deutscher Akademischer Austausch Dienst DAAD

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