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Title of Journal: J Cancer Res Clin Oncol

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Abbravation: Journal of Cancer Research and Clinical Oncology

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Springer Berlin Heidelberg

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DOI

10.1002/sam.11305

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1432-1335

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Cryopreserved NK cells in the treatment of haemato

Authors: Monika Holubova Michaela Miklikova Martin Leba Daniel Georgiev Pavel Jindra Martin Caprnda Rachele Ciccocioppo Peter Kruzliak Daniel Lysak
Publish Date: 2016/09/10
Volume: 142, Issue: 12, Pages: 2561-2567
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Abstract

Leukaemia is an aggressive cancer of haematopoiesis Despite increasing treatment success the relapse rate is still high Natural killer NK cells play a key role in the immune response to malignancies thus it is conceivable that NK cellbased immunotherapy may control relapses while extending the diseasefree survival In our study we investigated whether cryopreserved NK cells are able to kill the leukaemic K562 cell line the necessity of IL2 coapplication and the association of activation marker expression NKp44 NKG2D and CD25 with cytotoxic potentialOur results demonstrated the ability of cryopreserved NK cells to kill K562 in all ratios times and culture conditions The number of dead K562 cells depended on the number of NK cells and on the presence of IL2 NK cells cytotoxic potential decreased gradually in the culture without IL2 In contrast NK cellmediated cytotoxicity remained the same during the entire reculture period after IL2 reapplication

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