Authors: M Akif Öztürk İhsan Ertenli Sedat Kiraz İbrahim C Haznedaroğlu İsmail Çelik Şerafettin Kirazlı Meral Çalgüneri
Publish Date: 2003/05/15
Volume: 24, Issue: 2, Pages: 98-102
Abstract
Behçets disease BD commonly presents with articular manifestations and thrombotic vasculopathy Arthritis of BD characteristically demonstrates a recurrent and nondestructive course The pathobiological basis of the thrombotic vasculopathy and protective factors against cartilage destruction in arthritis of BD have not been elucidated Apart from being involved in fibrinolysis and thrombolysis the plasminogen activation system can contribute to the pathogenesis of destructive joint diseases such as rheumatoid arthritis RA Plasminogen activator inhibitor1 PAI1 is a well known fibrinolysis inhibitor In this study local synovial fluid and circulating plasma PAI1 concentrations of BD were assessed in comparison to RA patients and healthy controls to investigate the nonerosive nondestructive nature of Behçet arthritis Twelve patients with BD mean age 34±11 years malesfemales 66 15 with RA mean age 36±8 years malesfemales 312 and 15 healthy adults mean age 32±10 years malesfemales 69 were included in this study Plasma PAI1 antigen levels and PAI1 activities were significantly greater in BD patients than in RA patients and healthy controls P0001 Synovial fluid levels of both parameters were also higher than in RA patients P0001 These results suggest that PAI1 may promote hypofibrinolysis of Behçets vasculopathy and also have a protective role in the arthritis of BD
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