Authors: Zhenhua Duan Faming Pan Zhen Zeng Tianchen Zhang Sheng Wang Guixing Li Shengqian Xu Jianhua Xu Li Zhang
Publish Date: 2011/01/21
Volume: 32, Issue: 5, Pages: 1209-1214
Abstract
Up to now many publications have evaluated the correlation between IL23R polymorphisms and ankylosing spondylitis with conflicting results We perform this metaanalysis to collect all the relevant studies up to date to further clarify the association of IL23R polymorphisms with AS Relevant published data were retrieved through Medline PubMed Embase Web of Science CNKI Chinese BioMedical Literature Database on disc and the statistical analysis was conducted using Stata 110 1 A total of 11 literatures including 13 population samples were studied 2 The allele A frequency of rs11209032 was higher in the AS group than in the controls A vs G OR = 1173 95 CI = 1107–1243 P 0001 3 The allele A of rs1004819 was higher in the AS group than in the controls in both allpooled population A vs G OR = 1147 95 CI = 1022–1287 P = 002 and Europepooled population A vs G OR = 1199 95 CI = 1007–1429 P = 0042 4 The allele frequency T of rs1343151 G of rs10489629 and A of rs11209026 was lower in the AS group than in the controls 5 No significant differences were found in allele frequency of rs10889677 polymorphism between cases and controls by random effects model We concluded that the genetic susceptibility for AS is associated with the IL23R gene polymorphisms The protective SNPs include rs1343151 rs10489629 and rs11209026 while rs1004819 and rs11209032 may be the susceptibility SNPs
Keywords: