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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer-Verlag

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DOI

10.1007/s11431-011-4334-z

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1437-160X

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Serum antioxidants and nitric oxide levels in fibr

Authors: Omer Faruk Sendur Yasemin Turan Engin Tastaban Cigdem Yenisey Mukadder Serter
Publish Date: 2008/10/14
Volume: 29, Issue: 6, Pages: 629-633
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Abstract

We proposed to assess antioxidant status and nitric oxide in fibromyalgia FM patients in comparison to healthy controls Additionally the association between the serum antioxidant levels and clinical findings in FM patients was also investigated Thirtyseven FM patients and 37 healthy controls were enrolled in this study Severity of fatigue and pain were determined by Visual Analogue Scale Functional capacity in daily living activities was evaluated by fibromyalgia impact questionnaire Serum NO catalase and glutathione were measured Serum glutathione and catalase levels were significantly lower in FM patients than controls However no significant difference was seen in serum NO levels between the two groups A significant correlation was evident between serum NO level and pain Additionally the correlation between glutathione level and morning stiffness was found to be significant These findings support other studies we assume that these two antioxidants might have impact on the pathogenesis of FM disease

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