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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer-Verlag

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DOI

10.1007/978-3-319-00455-6

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1437-160X

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Possible antimetastatic effect of Iloprost in a p

Authors: Yavuz Pehlivan Ibrahim Halil Turkbeyler Ozan Balakan Alper Sevinc Mustafa Yilmaz Kemal Bakir Ahmet Mesut Onat
Publish Date: 2011/03/30
Volume: 32, Issue: 5, Pages: 1437-1441
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Abstract

Systemic Sclerosis SSc is a chronic disease of unknown etiology which affects the vascular system and connective tissue A wide series of studies showed an increased prevalence of cancer in patients with SSc than the normal population Prostacyclin PGI2 is an endogenously produced element that is basically synthesized by arachiodonic acid through prostacyclin synthesis in vascular system endothelial cells Iloprost is a stable analogue of PGI2 which is used in the treatment of pulmonary arterial hypertension PAH In a limited number of animal models the antimetastatic activity of PGI2 is observed Herein we report iloprost treatment of a 60yearoldwoman with SSc who lately developed PAH as a complication of her disease and lung adenocarcinoma as a coincidence simultaneously These two mortal complications were both treated successfully with inhaled iloprost until her death due to gastrointestinal complications of SSc

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