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Title of Journal: Rheumatology International

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Abbravation: Rheumatology International

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Springer-Verlag

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DOI

10.1002/cne.903060303

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1437-160X

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Measurement of transcription factor cfos and EGR

Authors: B Grimbacher W K Aicher H H Peter H Eibel
Publish Date: 2014/02/09
Volume: 17, Issue: 3, Pages: 109-112
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Abstract

The transcription factors Fos and EGR1 are known to be involved in the regulation of the transcription of metalloproteinases and their specific inhibitors Since the overexpression of metalloproteinases is responsible for the matrix degradation in rheumatoid arthritis RA exact analysis of transcription levels of cfos and EGR1 ex vivo may serve to monitor progression or remission of the disease activity in RA Here we report on a method based on a quantitative reverse transcription polymerase chain reaction RTPCR for rapid estimation of the transcription levels of the immediate early genes cfos and EGR1 Coamplification with suitable internal standards easily generated by the use of hybrid primers allows us to semiquantitatively measure cfos and EGR1 induction levels in low numbers of cultured cells or very small tissue samples obtained by synovial biopsy The sensitivity of the method was 35 pg/ml for cfos and 10 pg/ml for EGR1specific cDNAs

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