Authors: Aniel J L BrambilaTapia Jorge I GámezNava Laura GonzálezLópez Lucila SandovalRamírez Julio MedínaDíaz Montserrat Maldonado Sergio R GutierrezUreña Gloria MartínezBonilla Beatriz T MartínMárquez Mónica Vázquez del Mercado Arnulfo NavaZavala José F MuñozValle Mario SalazarPáramo Ingrid P DávalosRodríguez
Publish Date: 2010/03/24
Volume: 31, Issue: 8, Pages: 1065-1068
Abstract
The objective of this study is to establish whether there is an association between the presence of FCGR3A V176 polymorphism with SLE or its manifestations We included 94 patients according to the 1982 ACR criteria as well as 98 controls matched by age and gender The 11 ACR diagnostic criteria were analyzed on the clinical files The polymorphism FCGR3A V176 was determined by direct sequencing There was not an association between the polymorphism FCGR3A V176 with SLE or its main manifestations The allelic frequency for F176 was 080 and 072 in cases and controls respectively P = 009 IC95 042–107 and the genotypic frequency in the group of cases was 065 for homozygotes F176/F176 030 for heterozygotes and 005 for the homozygotes V176/V176 while for the control group it was 053 039 and 008 respectively The polymorphism FCGR3A V176 is not associated with SLE or any of its manifestations in patients with SLE from the West of Mexico
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