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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer Berlin Heidelberg

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DOI

10.1016/0029-5582(65)90022-2

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1437-160X

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Apropos ‘Association of suboptimal 25hydroxyvitam

Authors: Subhash C Arya Nirmala Agarwal
Publish Date: 2013/03/17
Volume: 34, Issue: 4, Pages: 587-587
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Abstract

We compliment Abu El Maaty et al 1 for their meticulous investigations to assess the incidence of vitamin D deficiency in postmenopausal women at the Rheumatology outpatient clinic at the AlKasr AlAini Medical University Hospital at New Cairo City Egypt and concur that randomised control trials are desirable to decide the dose schedules for vitamin D supplementation in postmenopausal women Nevertheless it would also be important to carry out comparable investigations at different nonacademic nonresearch health care centres in different Egyptian regionsAlthough all vitamin D estimations as serum 25hydroxyvitamin D at the AlKasr AlAini Medical University Hospital were carried out employing the ‘gold standard’ technology of highperformance liquid chromatography method HPLC not many hospital or health care centres elsewhere would be equipped to carry out HPLC in their premises They would have to employ commercially available enzymelinked immunosorbent assay ELISA kits for serum 25hydroxyvitamin D measurements A beginning towards an inhouse standardisation could be made in individual laboratories by picking up blood samples from cases with a high or level serum 25hydroxyvitamin D level and to prepare its 20 aliquots By testing such aliquots repeatedly it would be possible to work out local mean serum 25hydroxyvitamin D level and standard deviation SD 2Vitamin D deficiency is a global phenomenon afflicts about one billion people worldwide 3 In resourcepoor countries with vast population of masses with vitamin D deficiency the laboratory infrastructure is poor 4 and it would not be feasible to assay vitamin D level even by ELISA technology Simpler pointofcare rapid tests are needed to quantify 25hydroxyvitamin D level levels in the clinicians’ premises and in laboratory setup at primary health care centre laboratoriesLast but not least future plans towards vitamin D supplementation in postmenopausal women in Egypt 1 should include both vitamin D3 supplementation and a watch on postsupplementation vitamin D3 levels A daily supplementation of 1000 IU of vitamin D3 may fail to bring levels to a minimum of 75 nmol/l in 20–30  cases 5

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