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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer Berlin Heidelberg

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DOI

10.1007/bf03052566

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1437-160X

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Association of XRCC1 Arg399Gln and Arg194Trp polym

Authors: Mengle Peng Xueliang Zhou Xianfei Ding Liqiang Wei Yong Zhao Tao Zhu Xiaoqing Shi Dongchun Qin
Publish Date: 2016/11/03
Volume: 37, Issue: 3, Pages: 435-444
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Abstract

The role of the Xray repair crosscomplementing gene 1XRCC1 Arg399Gln and Arg194Trp polymorphisms has been involved in the investigations of susceptibility to multiple autoimmune diseases but the results were inconsistent Here we have performed a metaanalysis to clarify the relationship between them All appropriate case–control studies were searched in the PubMed EMBASE and Chinese National Knowledge Infrastructure CNKI database A metaanalysis was conducted on the association between the XRCC1 two polymorphisms Arg399Gln Arg194Trp and risk of autoimmune diseases Pooled odds ratios OR with 95 confidence intervals CI were conducted to assess the association Fourteen relevant studies with a total of 2886 cases and 3257 controls were analyzed in our research Analysis for the XRCC1 Arg399Gln polymorphism under recessive model OR 153 95 CI 107–218 P = 0019 dominant model OR 136 95 CI 104–177 P = 0026 and homozygous model OR 167 95 CI 107–262 P = 0024 indicated an association in the overall population as well as in Caucasian populations under the recessive model OR 173 95 CI 103–291 P = 0039 and Asian populations under dominant model OR 131 95 CI 102–170 P = 0037 Stratification by disease indicated significant association between XRCC1 Arg399Gln and rheumatoid arthritis RA in all genetic models P  005 However there was no significant association between XRCC1 Arg194Trp polymorphism and autoimmune diseases in different genetic models The current metaanalysis demonstrates that the XRCC1 Arg399Gln polymorphism confers susceptibility to autoimmune diseases in Asians and Caucasians and in particular shows that XRCC1 Arg399Gln polymorphism is associated with RAMP and XZ contributed to conception and design of the study acquisition and interpretation of data drafting the article and final approval of the version to be published XD and LW helped in acquisition of data analysis and interpretation of data revising the article and final approval of the version to be published YZ TZ and XS contributed to drafting and revising the article and final approval of the version to be published

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