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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer-Verlag

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DOI

10.1007/bf02651943

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1437-160X

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A singlenucleotide polymorphism of the TNFSF4 gen

Authors: ShengQuan Zhang JianWen Han LiangDan Sun Wensheng Lu XianYong Yin XueJun Zhang Sen Yang
Publish Date: 2009/12/13
Volume: 31, Issue: 2, Pages: 227-231
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Abstract

Systemic lupus erythematosus SLE is a prototypic autoimmune disease with complex genetic inheritance Recently singlenucleotide polymorphisms SNPs in tumor necrosis factor TNF superfamily gene TNFSF4 have been shown to be associated with SLE in European and Hong Kong Chinese populations But it is unknown whether it is also associated with the disease in Mainland Chinese Han population We genotyped the SNPs rs1234315 near the TNFSF4 gene in 1344 SLE patients and 4315 controls of Chinese Han population and confirmed the association between the SNP and the SLE odds ratios ORs of 145 and P values of 15 × 10−16 The stratification analyses showed that rs1234315 was more strongly associated with SLE patients with arthritis Our study not only suggested that the TNFSF4 gene was associated with SLE in Chinese Han population but also implied that it might be a common genetic factor predisposing to the development of SLE in multiple populations

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