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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer-Verlag

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DOI

10.1007/s10055-008-0086-x

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1437-160X

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Different genetic effect of PXK on systemic lupus

Authors: EunMi Kim SoYoung Bang IL Kim Hyoung Doo Shin Byung Lae Park HyeSoon Lee SangCheol Bae
Publish Date: 2011/01/18
Volume: 32, Issue: 1, Pages: 277-280
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Abstract

PXK was identified as a novel candidate gene for systemic lupus erythematosus SLE from genomewide association studies GWAS in Caucasians But a recent replication study in Hong Kong Chinese reported that PXK was not associated with SLE The aim of this study was to determine whether PXK is associated with SLE in Koreans We genotyped single nucleotide polymorphism SNP rs6445975 of PXK using the TaqMan assay in 527 Korean patients with SLE and 517 healthy Korean control subjects Genotypic associations were assessed using multiple logistic regression models Additional analyses were also performed by subphenotype stratification No association was detected between PXK rs6445975 and SLE odds ratio OR = 106 P = 057 PXK rs6445975 showed positive associations with photosensitivity P = 002 and the production of antiSm Ab P = 004 among SLE patients Thus the association of PXK rs6445975 with SLE that was previously observed in Caucasians was not replicated in Koreans or in Hong Kong Chinese It is possible that PXK has different genetic contribution on SLE between Caucasians and Asians and that the gene is associated with disease subphenotypes rather than with overall susceptibilityWe are grateful to JungAh Kim YoungHi Lee and EunKyoung Ju for assistance with sample preparation and data collection This study was supported by a grant from the Korea Healthcare technology RD Project Ministry for Health Welfare and Family Affairs Republic of Korea A080588 A010252

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