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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer-Verlag

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DOI

10.1016/j.apt.2014.11.003

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1437-160X

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New developments in ochronosis review of the lite

Authors: Julie M Keller William Macaulay Ohannes A Nercessian Israeli A Jaffe
Publish Date: 2004/08/21
Volume: 25, Issue: 2, Pages: 81-85
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Abstract

Ochronosis commonly affects all connective tissue Recognition of changes secondary to the deposition of ochronotic pigments has increased with advances in diagnostic technology allowing both improved imaging and early biochemical and geneticsbased diagnosis of alkaptonuria the cause of ochronosis Successful symptomatic treatment of ochronotic arthropathy with joint replacement has been documented and a new pharmacotherapeutic agent nitisinone is currently under investigation for both prevention and treatment of ochronosis This review of the literature highlights recently recognized complications new diagnostic techniques and treatment options

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