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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer-Verlag

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DOI

10.1007/bf01023755

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1437-160X

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Serum nitric oxide catalase superoxide dismutase

Authors: Salih Ozgocmen Sadık Sogut Ozge Ardicoglu Ersin Fadillioglu Irfan Pekkutucu Omer Akyol
Publish Date: 2003/06/17
Volume: 24, Issue: 2, Pages: 80-83
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Abstract

In this study serum antioxidant and oxygen derived free radical status of patients with ankylosing spondylitis AS was investigated and compared with that of age and sexmatched healthy controls The relationship of these parameters to disease activity indices was also examined Thirty patients with AS not currently under diseasemodifying antirheumatic drug DMARD treatment eg sulfasalazine or methotrexate 15 active and 15 inactive and 16 age and sexmatched healthy controls were included in the study Catalase EC 11116 total CuZn and Mn superoxide dismutase SOD EC 11511 activities and malondialdehyde MDA nitrite NO2 and nitrate NO3 levels as indices of nitric oxide NO production were evaluated using appropriate methods There was no statistically significant difference found in SOD activity or NO and MDA levels between active and inactive patients Inactive patients showed no significant difference in all the measured oxidant/antioxidant parameters when compared to healthy controls Active patients had significantly higher levels of MDA and catalase enzyme activity P=0002 and P=0007 respectively There was no significant correlation between oxidant/antioxidant parameters and disease activity Creactive protein erythrocyte sedimentation rate or Bath Ankylosing Spondylitis Disease Activity Index CRP ESR or BASDAI in either group except catalase enzyme activity which had a significant correlation with CRP and ESR levels in active patients r=069 and P=0004 r=052 and P=004 respectively Our results indicate that oxidative stress and lipid peroxidation are accelerated in untreated patients with active AS Serum catalase activity may be closely related to disease activity In this regard we underscore the likely benefit of some therapeutic interventions including highpotential antioxidants that will potentiate the antioxidant defense mechanism and reduce peroxidation in the management of AS

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