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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer Berlin Heidelberg

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DOI

10.1007/bf02786931

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ISSN

1437-160X

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Expanding the therapeutic options for renal involv

Authors: Savino Sciascia Massimo Radin Jinoos Yazdany Maria Tektonidou Irene Cecchi Dario Roccatello Maria Dall’Era
Publish Date: 2017/03/03
Volume: 37, Issue: 8, Pages: 1249-1255
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Abstract

In this study we aimed to systematically review available literature on the efficacy of eculizumab for the treatment of renal involvement in patients with systemic lupus erythematosus SLE We conducted a literature search developed a priori to identify articles reporting clinical experience with the use of eculizumab in SLE patients focusing on renal involvement The search strategy was applied to Ovid MEDLINE EMBASE InProcess and Other NonIndexed Citation Cochrane Central Register of Controlled Trials and Scopus from 2006 to present Abstracts from EULAR and ACR congresses were also screened We included six publications describing the renal outcome in SLE patients receiving eculizumab Five out of six cases described the occurrence of thrombotic microangiopathy TMA in renal biopsies of patients with known SLE three cases with biopsyproven lupus nephritis LN and two patients with SLErelated antiphospholipid syndrome without histologic evidence of LN One study reported the outcome of a patient with severe refractory LN successfully treated with eculizumab All patients regardless of the presence of concomitant LN presented with severe hypocomplementemia and renal function impairment All patients showed a sustained improvement of renal function and normalization of complement parameters after treatment with eculizumabmedian followup 9 months 1–17 Despite the limitations of the currently available evidence existing data are promising and provide preliminary support for the use of eculizumab in selected cases of SLE with renal involvement especially in the presence of TMA or in patients with refractory LNThe authors declare no conflict of interest and declare no support from any organisation for the submitted work no financial relationships with any organisations might have an interest in the submitted work in the previous 3 years and no other relationships or activities that could appear to have influenced the submitted work

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