Authors: Nancy J Olsen Maha Yousif Azza Mutwally Melinda Cory Nada Elmagboul David R Karp
Publish Date: 2013/05/30
Volume: 33, Issue: 10, Pages: 2585-2590
Abstract
The objective of this study was to characterize organ damage in lupus patients enrolled in Dallas Regional Autoimmune Disease Registry DRADR Retrospective chart review was carried out on 99 patients with four or more diagnostic criteria for systemic lupus erythematosus SLE and 15 with less than four of these criteria who were designated as having incomplete lupus erythematosus ILE The majority of patients 84 were African American or Hispanic/Latino mean disease duration was 95 years The mean damage score was 157 range 0–8 and a damage score greater than 0 was present in 64 of the patients The ILE group had lower mean damage scores 067 than the SLE group 167 P = 004 explained in part by the shorter disease duration in the ILE patients 433 vs 1024 years P = 0003 The most prevalent damage category was renal present in 24 of patients Malignancies occurred in individuals who were significantly older than those who had renal or peripheral vascular damage P = 00007 The findings confirm clinical impressions that DRADR includes a highrisk lupus population The ILE patients have less damage but also shorter disease duration suggesting that this might represent an earlier disease stage These results are consistent with the hypothesis that ILE patients include a subset that is likely to experience progressive organ damage Longitudinal study of these patients has significant likelihood of tracking the changes that are correlated with disease progression to SLEThis work was supported by NIH/NIAMS P50AR0455503 NJO is also supported in part under a grant with the Pennsylvania Department of Health using Tobacco CURE Funds The Department specifically disclaims responsibility for any analyses interpretations or conclusions We appreciate the assistance of Alice Cox Pratik Doshi Heidi Prather Justin Ribault and Sarmistha Sen for enrolling and evaluating the individuals enrolled in DRADR Michelle Christadoss and Ferdicia CarrJohnson processed the samples and carried out the laboratory assessments We are deeply indebted to our late colleague Valerie K Branch MS MBA whose dedication to establishing DRADR made this study possible
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