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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer Berlin Heidelberg

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DOI

10.1007/bf01387097

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ISSN

1437-160X

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Systemic sclerosis comparison of efficacy of oral

Authors: Hadi Poormoghim Nader Rezaei Zeinab Sheidaie Ali Reza Almasi Maziar MoradiLakeh Simin Almasi Elham Andalib
Publish Date: 2014/05/07
Volume: 34, Issue: 12, Pages: 1691-1699
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Abstract

The aim of this study was to evaluate efficacy of azathioprine AZA and cyclophosphamide CYC as a therapeutic regimen for interstitial lung disease associated with systemic sclerosis SSc Thirtysix selected patients included in this retrospective cohort and received one of the two drugs the first group consists of 15 patients who were treated with AZA 15–2 mg/kg/day and the second group with 21 patients received oral CYC up to 2 mg/kg/day Both groups received additional low dose of prednisolone ≤10 mg for 6 months Forced vital capacity FVC diffusion lung capacity for carbon monoxide DLCO and skin score were assessed as outcome measures Modified Rodnan skin score mRSS pulmonary function test and DLCO were evaluated at entry and at the end of study after 12 months The mean SD FVC percentages obtained at baseline and posttreatment in AZAtreated patients were 628 ± 98 and 711 ± 209 with mean difference of FVC +76 ± 131 p = 005 and in CYCtreated patients 595 ± 107 631 ± 162 and +29 ± 115 respectively p = 019 Baseline and posttreatment DLCO in AZAtreated patients were 614 ± 258 and 767 ± 240 with mean difference of +150 ± 145 respectively p = 001 In CYCtreated patients those measures were 677 ± 275 and 600 ± 229 with mean difference of −80 ± 237 p = 012 Following 12 months of treatment in AZAtreated patients mean difference of changes in mRSS was −29 ± 37 and −14 ± 45 in CYCtreated patients Our results indicated that AZA can be effective in ameliorating or stabilizing lung function in selected SSc patient groupsWe would like to acknowledge Firoozgar Clinical Research Development Center for their efforts in revision of this manuscript as well as Arash Jalali PhD from Tehran university of Medical Science Department of epidemiology and Biostatistics for his collaboration on this research project

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