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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer-Verlag

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DOI

10.1002/ppi.109

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1437-160X

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The effects of NSAIDs on types I II and III coll

Authors: YunSheng Ou Chao Tan Hong An DianMing Jiang ZhengXue Quan Ke Tang XiaoJi Luo
Publish Date: 2011/06/17
Volume: 32, Issue: 8, Pages: 2401-2405
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Abstract

The effects of longterm use of celecoxib ibuprofen and indomethacin on types I II and III collagen metabolism were evaluated in rat osteoarthritis OA model One hundred and thirty wistar rats were randomly divided into 4 groups the celecoxib group the ibuprofen group the indomethacin group and the normal saline group The osteoarthritis was induced by the excision of the left Achilles tendon In the 3rd 6th and 9th month of treatment after surgically induced osteoarthritis the articular cartilage was observed with microscope using HE staining The expression of proteoglycans was semiquantified using toluidine blue staining And the expressions of types I II and III collagen in chondrocytes were examined using immunohistochemistry The results suggested that celecoxib had no remarkable effects on the expression of types I II and III collagen Ibuprofen upgraded the expression of types I II and III collagen and increased the synthesis of collagen Indomethacin suppressed the expression of type II collagen and enhanced the expression of types I and III collagen Therefore during the longterm use of NSAIDs in osteoarthritis celecoxib may have no remarkable influences on collagen metabolism of the articular cartilage and may be the ideal choice in the treatment of chronic destructive joint disease when antiinflammatory drugs need to be used for a prolonged period Ibuprofen may be unfavorable and indomethacin may be harmful to collagen metabolism in OA treatment

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