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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer-Verlag

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DOI

10.1002/ange.19780900821

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1437-160X

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Comparison of modern marker proteins in serum and

Authors: S Andereya N Streich B SchmidtRohlfing T Mumme R MüllerRath U Schneider
Publish Date: 2005/07/06
Volume: 26, Issue: 5, Pages: 432-438
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Abstract

Numerous studies have focused on the significance of modern marker proteins in the synovial fluid of the knee joint and in the serum both for osteoarthritis OA and rheumatoid arthritis RA The relationship between the serum concentrations and the concentrations in the synovial fluid is still unclear Synovial fluid and serum samples were obtained from 13 patients with advanced OA and from 8 patients with severe RA and concentrations of MMP1 MMP3 MMP13 TIMP1 COMP and MIA/CDRAP were determined All values were normalized against the total protein concentrations Serum concentrations of MMP13 in the RAgroup were statistically higher than the synovial values P005 MMP13 was the only marker protein that revealed distinct higher levels in the serum than in the synovial fluid The study design allows only conclusions about advanced stages of RA and OA Longitudinal investigations may provide further information about the value of MMP13 as a potential marker to monitor the course of RA and OA

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