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Title of Journal: Rheumatol Int

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Abbravation: Rheumatology International

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Springer Berlin Heidelberg

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DOI

10.1016/0144-8617(89)90072-6

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ISSN

1437-160X

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No evidence for involvement of the tolllike recep

Authors: YuFeng Qing JingGuo Zhou Ming Li WenGuang Xie CuiPing Huang ShengPing Zeng Ling Yin
Publish Date: 2012/11/15
Volume: 33, Issue: 11, Pages: 2937-2941
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Abstract

Previous studies demonstrated that tolllike receptor TLR 4 was involved in the development of autoinflammatory disease including gouty arthritis GA TLR4 functional gene Asp299Gly and Thr399Ile polymorphisms play a role in some autoinflammatory disease susceptibility We undertook this study to analyze the association between the genetic polymorphisms within TLR4 gene and the susceptibility to GA in Chinese Han people Two functional variants Asp299Gly and Thr399Ile in the TLR4 gene were genotyped using 5′ exonuclease TaqMan® technology from 218 male GA patients and 226 ethnically matched controls None polymorphisms of Asp299Gly and Thr399Ile were detected in all GA cases and controls which indicates that there is no evidence for involvement of the TLR4 gene Asp299Gly and Thr399Ile polymorphisms in susceptibility to primary GA in the Chinese Han population Further studies with extended single nucleotide polymorphisms should be performed

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