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Title of Journal: Am J Hypertens

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Abbravation: American Journal of Hypertension

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Narnia

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DOI

10.1007/bf02418391

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0895-7061

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Intrarenal Arterial Network Renin Content and Inhi

Authors: Birt Pauline C Zimmerman Ben G
Publish Date: 1995/04/01
Volume: 8, Issue: 4_Pt_1, Pages: 433-436
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Abstract

The renin content expressed as nanograms of angiotensin I/hour/milligram of a rabbit intrarenal arterial network IAN was compared to that of renal cortical samples from the same animal Tissues from six rabbits were studied Cortical tissue RC and an IAN with some glomeruli and attached arterioles IAN + glomeruli were prepared from one kidney and an IAN freed of glomeruli IAN − glomeruli was obtained from the opposite kidney These tissues were homogenized and the supernatant incubated at pH 74 and 37°C for 30 to 60 min or 3 to 6 h Angiotensin I was generated in a linear fashion and the values averaged for the two incubation periods were 844 ± 266 121 ± 39 and 32 ± 11 ng/h/mg for RC IAN + glomeruli and IAN − glomeruli respectively A specific renin inhibitor EMD 58265 at 1 × 10−8 mol/L attenuated and at 5 × 10−8 mol/L almost totally abolished angiotensin I production The results indicate that small arteries comprising the IAN contain renin and that the enzymatic activity is most likely due to that protein and not another aspartyl protease Am J Hypertens 19958433436

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  8. G19Superiority of 3d VS 2d echocardiography for measurement of left ventricular mass: an in vivo canine anatomic validation.
  9. Role of Sex Steroids in Modulating Tumor Necrosis Factor Alpha-Induced Changes in Vascular Function and Blood Pressure
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  11. P-403: Effect of short-term supplementation of potassium chloride and potassium citrate on blood pressure in patients with untreated essential hypertension
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  13. Arterial compliance changes in diabetic normotensive patients after angiotensin-converting enzyme inhibition therapy
  14. G10Cardiovascular reactivity to mental stress task and serum lipid levels in young mildly hypertensive subjects?
  15. Evaluation of antihypertensive therapy with the combination of olmesartan medoxomil and hydrochlorothiazide
  16. G34Effects of a restricted sleep regimen on ambulatory blood pressure monitoring in normotensive subjects
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  18. Retinol-Binding Protein and Transferrin in UrineNew Markers of Renal Function in Essential Hypertension and White Coat Hypertension?
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  47. Erratum
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