RetinolBinding Protein and Transferrin in UrineNe

Authors: Bang Lia E Holm Jan Svendsen Tage L

Publish Date: 1996/10/01

Volume: 9, Issue: 10, Pages: 1024-1028

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Abstract

Lia E Bang Jan Holm Tage L Svendsen RetinolBinding Protein and Transferrin in Urine New Markers of Renal Function in Essential Hypertension and White Coat Hypertension American Journal of Hypertension Volume 9 Issue 10 October 1996 Pages 1024–1028 https//doiorg/101016/0895706196001124We studied the 24 h urinary excretion of albumin transferrin immunoglobulin G and retinolbinding protein in individuals with essential hypertension white coat hypertension and normotension In 56 individuals we measured the 24 h ambulatory blood pressure AMBP The individuals could be divided into three groups 26 hypertensives 14 white coat hypertensives and 16 normotensives Daytime AMBP values were median values with range in parentheses mm Hg hypertensives 158/105 198 to 121/95 to 120 white coat hypertensives 141/83 161 to 129/72 to 90 and normotensives 123/75 148 to 102/63 to 86 We determined with immunochemical methods the 24 h urinary excretions of albumin transferrin and immunoglobulin G all markers of glomerular dysfunction and retinolbinding protein a marker of impaired proximal tubular function We found a significantly higher excretion of albumin and transferrin in hypertensives P 0000/P 0001 and in white coat hypertensives P 003 /P 02 compared to normotensives Out of 26 hypertensives seven had microalbuminuria ≥30 to 300 mg albumin/ 24 h Two cases of microalbuminuria were found among the 14 white coat hypertensivesImmunoglobulin G excretion was not significantly increased in any of the hypertensive groups Retinolbinding protein excretion was significantly higher in hypertensive patients P 007 whereas no elevation was observed in persons with white coat hypertension In hypertensives a significant correlation was found between urinary excretion of albumin and transferrin and office blood pressure and systolic AMBP There was no significant correlation between the urinary excretions of IgG and retinolbinding protein and blood pressures in any of the three groups Our findings indicate that patients with white coat hypertension like hypertensives have a selective type of glomerular dysfunction However proximal tubular dysfunction was seen only in hypertensives Urinary excretions of albumin transferrin and retinolbinding protein may be useful as markers of glomerular and tubular dysfunction in essential hypertension

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