Authors: Cesaretti Mario LR Ginoza Milton Zanella Maria T Ribeiro Artur B Kohlmann Osvaldo
Publish Date: 2005/05/01
Volume: 18, Issue: S4, Pages: 195A-195A
Abstract
Mario LR Cesaretti Milton Ginoza Maria T Zanella Artur B Ribeiro Osvaldo Kohlmann P517 Increased dietary sodium partially blunts the amelioration of insulin resistance induced by dietary potassium supplementation in a neuroendocrine model of visceral obesity American Journal of Hypertension Volume 18 Issue S4 May 2005 Page 195A https//doiorg/101016/jamjhyper200503534 The aim of this study was to evaluate the effects of increased contents of potassium alone or potassium + sodium chloride in the diet upon tail arterial pressure TAP and glucose metabolism of Wistar rats with visceral obesity induced by neonatal administration of MSG 2 mg/day/SC from day 1t o11th after birth a model with insulin resistanceMSG 2 mg/kg/day was administered to newborn Wistar rats during the first 11 days of life At 3 months of age they were separated into 3 groups and were feed for 12 weeks with group1regular rat chow + tap water to drink MSG n= 13 group 2potassium enriched diet K+ content 3 times standard chow + tap water to drink MSGK+ n=12 and group 3 same diet of group 2 but receiving 1 saline to drink instead tap water MSG+K+Na n=12 Rats receiving vehicle instead MSG injections at neonatal period and feed with regular rat chow C n= 12 or potassium enriched chow C+K n= 10 and tap water to drink were used as controls At the end of the followup period an oral glucose tolerance test OGTT glucose overload 68 mg/kg was performed in all animals Areas under the curves of glucose AUCG mg/dl and insulin AUCI mU/l and the insulin sensitivity index ISI mg—1mU—1 were determined Upon animals sacrifice the left ventricle was weightedDietary potassium supplementation decreases blood pressure and improves glucose metabolism of MSGinduced visceral obese rats and this effect is partially blunted by dietary sodium overload Improvement in the insulin sensitivity may account for the effects of dietary potassium supplementation on blood pressure
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