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Title of Journal: Am J Hypertens

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Abbravation: American Journal of Hypertension

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Narnia

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DOI

10.1002/zaac.19402430301

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0895-7061

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P269 Correlation between ascending aortic pressu

Authors: Chirinos Julio A Zambrano Juan P Chakko Simon Veerani Anila Schob Alan Perez Guido O Mendez Armando J
Publish Date: 2005/05/01
Volume: 18, Issue: S4, Pages: 103A-103A
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Abstract

Julio A Chirinos Juan P Zambrano Simon Chakko Anila Veerani Alan Schob Guido O Perez Armando J Mendez P269 Correlation between ascending aortic pressures and outcomes in patients with coronary artery disease American Journal of Hypertension Volume 18 Issue S4 May 2005 Page 103A https//doiorg/101016/jamjhyper200503287We prospectively followed 324 males undergoing coronary angiography for 1161±418 days Ascending aortic pressures were obtained during catheterization We analyzed central systolic blood pressure SBP diastolic blood pressure DBP and pulse pressure PP The study endpoints were 1 A combined endpoint of major adverse cardiovascular events MACE including unstable angina myocardial infarction coronary revascularization stroke or death or 2 Allcause mortality Cox regression was used to assess the association of aortic pressures with the risk of reaching the study endpointsThe PP significantly predicted MACE HR per 10 mmHg increase=109 95CI=1002117 p=004 The DBP was inversely correlated with the risk of MACE HR per 10 mmHg increase=085 95CI=074098 p=002 These correlations remained significant after adjusting for other predictors including diabetes mellitus current smoking congestive heart failure the left ventricular ejection fraction Creactive protein and the Charlson comorbidity score and other potential confounders including serum creatinine and the number of vessels involved with hemodynamically significant CAD The peripheral DBP but not the PP inversely correlated with the risk of MACE HR=087 per 10 mmHg increase 95CI=0750998 p=0047The aortic PP significantly predicted death HR per 10 mmHg increase=118 95CI=105133 p=0004 In addition the aortic DBP inversely correlated with the risk of death HR 076 95CI=062094 p=001 These correlations were independent of other predictors When adjusted for each other the aortic DBP and aortic PP were independent predictors of mortality The peripheral PP did not correlate with the risk of deathIn patients with angiographically demonstrated CAD aortic PP correlated positively whereas aortic DBP correlated negatively with the risk of MACE and death this correlation was independent of other risk markers and the angiographic severity of CAD

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