Journal Title
Title of Journal: Am J Hypertens
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Abbravation: American Journal of Hypertension
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Authors: Cohn Jay N Julius Stevo Neutel Joel Weber Michael Turlapaty Prasad Shen Yannan Dong Victor Batchelor Alicia Guo Weinong Lagast Hjalmar
Publish Date: 2004/02/01
Volume: 17, Issue: 2, Pages: 134-138
Abstract
Jay N Cohn Stevo Julius Joel Neutel Michael Weber Prasad Turlapaty Yannan Shen Victor Dong Alicia Batchelor Weinong Guo Hjalmar Lagast Clinical experience with perindopril in AfricanAmerican hypertensive patients a large United States community trial American Journal of Hypertension Volume 17 Issue 2 February 2004 Pages 134–138 https//doiorg/101016/jamjhyper200309017The effectiveness and safety of perindopril was evaluated in hypertensive AfricanAmerican patients n = 1412 and hypertensive white patients n = 7745 who had participated in a large United States community trial Patients received perindopril 4 mg once daily for 6 weeks Based on physicians’ clinical judgment at week 6 the dose was either maintained or increased to 8 mg for an additional 6 weeksReduction of blood pressure BP was significant with perindopril monotherapy 4 to 8 mg once daily in African Americans and whites P 001 The magnitude of BP reduction was significantly more in whites P 001 Uptitration of perindopril achieved additional BP reduction in both ethnic groups P 001 Control of BP 140/90 mm Hg in elderly 65 years of age and diabetic AfricanAmericans subgroups was achieved in 321 and 316 respectively Perindopril was safe and well toleratedIn the United States the incidence of hypertension is higher among African Americans compared with other ethnic groups The prevalence of hypertension in adult African Americans is about 33 compared with the incidence of 25 in individuals of white ethnicity1 Furthermore African Americans are known to carry multiple cardiovascular risk factors associated with hypertension resulting in higher rates of morbidity and mortality2The management of hypertension in African Americans presents challenges for practicing physicians Although angiotensinconverting enzyme inhibitors ACEIs are established as a major drug class in the treatment of hypertension the perception in clinical practice is that ACEIs are less effective as monotherapy in African Americans because of low renin levels and a high degree of salt sensitivity3 The efficacy and safety of perindopril an ACEI was investigated in a subgroup of African Americans from a large United States community trial4This was an open label baselinecontrolled study of 12 weeks’ duration The objective of the study was to assess the effectiveness of perindopril monotherapy administered once a day on the sitting systolic blood pressure SBP and diastolic blood pressure DBP
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References
citation title=Management of high blood pressure in African Americans consensus statement of the Hypertension in African Americans Working Group of the International Society on Hypertension in Blacks citation author=the Hypertension in African Americans Working Group citation author=Douglas JG citation author=Bakris GL citation author=Epstein M citation author=Ferdinand KC citation author=Ferrario C citation author=Flack JM citation author=Jamerson KA citation author=Jones WE citation author=Haywood J citation author=Maxey R citation author=Saunders E citation author=Schiffrin EL citation author=Sica DA citation author=Sowers JR citation author=Vidt D citation journal title=Arch Intern Med citation year=2003 citation volume=163 citation pages=525541
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- Effect of Sodium on Blood Pressure, Cardiac Hypertrophy, and Angiotensin Receptor Expression in Rats
- P-470: Cardiovascular risk factors in the elderly. accuracy of attention in primary care
- I37AN EXAMPLE OF RESEARCH IN HYPERTENSION IN LATIN AMERICA.
- P-132: Chronic cocaine abuse as a cause of left ventricular hypertrophy?
- P-405: Prevalence of asymptomatic coronary artery disease in men with vasculogenic erectile dysfunction: A prospective angiographic study
- P-554: Pulse pressure as a predictor factor for survival in patients with acute ishaemic stroke
- P-322: Impact of ambulatory pulse pressure and office pulse pressure on left ventricular hypertrophy in patients with essential hypertension
- G19Superiority of 3d VS 2d echocardiography for measurement of left ventricular mass: an in vivo canine anatomic validation.
- Role of Sex Steroids in Modulating Tumor Necrosis Factor Alpha-Induced Changes in Vascular Function and Blood Pressure
- P-269: Correlation between ascending aortic pressures and outcomes in patients with coronary artery disease
- P-403: Effect of short-term supplementation of potassium chloride and potassium citrate on blood pressure in patients with untreated essential hypertension
- P-403: Effect of short-term supplementation of potassium chloride and potassium citrate on blood pressure in patients with untreated essential hypertension
- Arterial compliance changes in diabetic normotensive patients after angiotensin-converting enzyme inhibition therapy
- G10Cardiovascular reactivity to mental stress task and serum lipid levels in young mildly hypertensive subjects?
- Evaluation of antihypertensive therapy with the combination of olmesartan medoxomil and hydrochlorothiazide
- G34Effects of a restricted sleep regimen on ambulatory blood pressure monitoring in normotensive subjects
- Effect of recombinant human erythropoietin therapy on ambulatory blood pressure in normotensive and in untreated borderline hypertensive hemodialysis patients
- Retinol-Binding Protein and Transferrin in UrineNew Markers of Renal Function in Essential Hypertension and White Coat Hypertension?
- P-397: Hypertension awareness, control and treatment in rural Mississippi: Morton Have-A-Heart Project
- Analysis of the 11β-Hydroxysteroid Dehydrogenase Type 2 Gene (HSD11B2) in Human Essential Hypertension
- P-481: Dopaminergic dilatation on cholinergic and electric induced contractions of rat isolated tracheal muscle
- P-298: Screening of adolescent hypertension, and evaluation of target organ damages. Results from the Debrecen hypertension study
- P-80: Diabetic masked hypertension: risk for stroke in Japanese
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- P-238: Heart rate variability and ECG changes in 148 Danish patients after two years in the VALUE trial
- Re: Heusser et al: elevation of sympathetic activity by eprosartan in young male subjects
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- P-272: BP control and CV outcomes in hispanic and nonhispanic women with CAD and hypertension: Findings from invest
- P-340: Renal insufficiency is the most prevalent target-organ disease in primary care-attended essential hypertension
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- ADVANCE in the Prevention of Cardiovascular Disease in Diabetic Patients
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- Reduction of Vessel Wall Inflammation in Hypertensive Patients: Is Physical Activity the Answer?
- P-241: Risk of cardiovascular events with amlodipine, lisinopril, or valsartan therapy in hypertension population
- P-357: Incidental renal artery stenosis in heart transplantation: Prevalence and clinical implications
- P-439: Hypertension and PLD2 regulation by D5 dopamine receptor
- Markers of Inflammation Are Inversely Related to Physical Activity and Fitness in Sedentary Men With Treated Hypertension
- P-517: Increased dietary sodium partially blunts the amelioration of insulin resistance induced by dietary potassium supplementation in a neuroendocrine model of visceral obesity
- Intrarenal Arterial Network Renin Content and Inhibition by EMD 58265
- P-692: 24-hr ambulatory mean blood pressure vs. pulse pressure as a predictor of silent cerebral infarcts in older Japanese hypertensives
- Interactions Between Melatonin and Estrogen in the Regulation of Blood Pressure in Women
- P-258: Prevalence, awareness, treatment and control of hypertension in Turkey (patent)
- B14The Effect Of Calcium And Vitamin D Supplements On Blood Pressure And Calcium Metabolism In Elderly Chinese.
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- C36AORTIC DISTENSIBILITY IN NORMOTENSIVE, UNTREATED AND TREATED HYPERTENSIVE PATIENTS.
- Erratum
- P-325: Impact of medical treatment during one month on systolic blood pressure, left ventricular systolic function and natriuretic peptides in patients with heart failure
- Incremental Expenditure of Treating Hypertension in the United States
- Antihypertensive Treatment Alters the Predictive Strength of Pulse Pressure and Other Blood Pressure Measures
- Association Between Different measurements of Obesity and the Incidence of Hypertension
- P-435: Evaluation of hypertension prevalence and blood pressure goal attainment using data from the 1999–2000 national health and nutrition examination survey (nhanes)
- P-140: E-prescription database analysis supports use of combination therapy in hypertensive patients with CAD in invest
- P-329: Cardiovascular morbid-mortality in hypertensive patients in relation to the presence of left ventricular hypertrophy. 11 years followed-up cohort
- D27COMPARATIVE EFFICACY OF HYDROCHLOROTHIAZIDE AND AMLODIPINE IN ELDERLY SUBJECTS WITH AMBULATORY HYPERTENSION.
- Exercise Activates Renal Dysfunction in Hypertension
- Myocardial Contrast Echocardiography: An Innovative Technique to Assess Myocardial Perfusion in Hypertensive Patients
- P-473: Hypertension in sub-Saharan Africa
- C18Relationship Between 24H Urinary Albumin Excretion Rate (Uae), Left Ventricular Mass Index (Lvmi) And 24H Ambulatory Blood Pressure (Abp) In Borderline Hypertensives (Bh) And Normotensive Offspring Of Hypertensive Parents.
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