Authors: Plauschinat Craig A Frech Feride H Gause Douglas Zhang Winnie
Publish Date: 2004/05/01
Volume: 17, Issue: S1, Pages: 120A-121A
Abstract
Craig A Plauschinat Feride H Frech Douglas Gause Winnie Zhang P241 Risk of cardiovascular events with amlodipine lisinopril or valsartan therapy in hypertension population American Journal of Hypertension Volume 17 Issue S1 May 2004 Pages 120A–121A https//doiorg/101016/jamjhyper200403316Using claims data from a national allpayer database Medstat MarketScan® a retrospective casecontrol study was performed Patients were included in the study if they met the following criteria 1 continuous enrollment 1998–2002 2 hypertension diagnosis ICD9CM 4011 between July 1998 and June 1999 3 no hypertensive therapy in first 6 months of l998 and 4 no CV event ICD9CM 402–448 between July 1999 and December 2000 Cases were patients who met inclusion criteria and had at least one CV event in 2001–2002 whereas controls did not have a CV event during the same time period Cases and controls were matched by age and gender The odds of prior drug exposure July 1998Dec 2000 among cases compared to controls were estimated using a conditional logistic regression which included a nonCV comorbidity index derived from the Charlson Index as a covariate505 cases and 505 controls were included The average age was 54 and 36 were female The mean comorbidity index was 03 for controls and 05 for cases Among controls 105 n=53 had taken amlodipine 87 n=44 had taken lisinopril and 4 n=20 had taken valsartan Higher percentages of cases had taken amlodipine 145 OR=14 P014 and lisinopril 131 OR=15 P007 However cases had a lower percent of valsartan users 28 compared to controls 40 OR=7 pvalue=38
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