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Title of Journal: Eur J Nutr

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Abbravation: European Journal of Nutrition

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Steinkopff-Verlag

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DOI

10.1007/978-94-009-4822-8_5

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1436-6215

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Effects of a new low dose soy protein/βsitosterol

Authors: Arrigo F G Cicero Monica Minardi Sifa Mirembe Egidio Pedro Antonio Gaddi
Publish Date: 2004/01/26
Volume: 43, Issue: 5, Pages: 319-322
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Abstract

The study was divided into 3 separate periods of 40 days each a stabilization diet period followed by a treatment period during which all subjects took 10 g of the test product once daily and finally a wash out period The following parameters were monitored weight dietary habits plasma lipid levels glycemia uric acid fibrinogenemia and antibodies against oxidized LDL oxLDL AbFrom the end of the stabilization diet period to the end of the supplementation with the soy protein product with added βsitosterol we observed a 1964 ± 2032 mg/dL 847 ± 5461 mg/dL 169 ± 1092 mg/dL and 706 ± 1666 mg/dL mean ± SD decrease respectively in LDLC p 0001 TG p = 0358 VLDLs p = 0358 and apoB p = 0016 levels associated with a 131 ± 808 mg/dL and 103 ± 1909 mg/dL mean increase respectively in HDLC p = 0251 and apoAI p = 0749 plasma concentrations The dietary supplementation did not influence Lpa p = 0984 and oxLDL Ab p = 0953 plasma levels A statistically significant correlation was observed for LDLC plasma levels between the end of the stabilization diet period and the end of the period of supplementation with soy proteins with added βsitosterols p 0001Although further longterm clinical studies are necessary before claims can be made regarding the therapeutic effects of the tested formulation the preliminary findings regarding its efficacy and safety as an antihypercholesterolemic agent are encouraging

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