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Title of Journal: Eur J Nutr

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Abbravation: European Journal of Nutrition

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D. Steinkopff-Verlag

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DOI

10.1016/0025-5416(76)90235-4

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ISSN

1436-6215

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‘Designer oils’ low in n6n3 fatty acid ratio be

Authors: Natalie D Riediger Nazila Azordegan Sydney HarrisJanz David W L Ma Miyoung Suh Mohammed H Moghadasian
Publish Date: 2009/03/31
Volume: 48, Issue: 5, Pages: 307-314
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Abstract

Cardiovascular benefits of dietary n3 fatty acids have been shown However benefits of n3 fatty acids as part of a high fat low n6n3 fatty acid ratio diet has not been fully characterized Aim of this study is to investigate cardiovascular and metabolic benefits of ‘designer oils’ containing a low ratio of n6n3 fatty acids in C57BL/6 mice Three groups of C57BL/6 mice were fed an atherogenic diet supplemented with either a fish oil or flaxseed oilbased ‘designer oil’ with an approximate n6n3 fatty acid ratio of 21 treated groups n = 6 each or with a safflower oilbased formulation with a high ratio 251 of n6n3 fatty acids control group n = 6 for 6 weeks Food intake body weight and blood lipid levels were monitored regularly Fatty acid profile of the heart tissues was assessed Histological assessment of liver samples was conducted At the end of the study body weight and food intake was significantly higher in the flax group compared to control The levels of 205n3 and 226n3 was significantly increased in the heart phospholipids in both flax and fish groups compared to control tissue 204n6 was significantly reduced in the fish group compared to control Significant liver pathology was observed in the control group only Lowering dietary ratio of n6n3 fatty acids may significantly reduce cardiovascular and metabolic risks in mice regardless of the source of n3 fatty acidsThis study was supported in part by Natural Sciences and Engineering Research Council of Canada Heart and Stroke Foundation and ARDI NR is a recipient of an NSERC Graduate Scholarship NA is a recipient of the Manitoba Graduate Studentship We would also like to thank Krystal Merrells Amy Kroeker Melissa Ree Rgia Othman and Aimee Cadieux for their technical and editorial support

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