Authors: Swapnil N Rajpathak Mathew S Freiberg Cuiling Wang Judith WylieRosett Rachel P Wildman Thomas E Rohan Jennifer G Robinson Simin Liu Sylvia WassertheilSmoller
Publish Date: 2009/10/13
Volume: 49, Issue: 4, Pages: 211-218
Abstract
Although several observational studies have consistently reported an inverse association between moderate alcohol consumption and risk of coronary heart disease CHD it is yet not well established if this association also exists among people with type 2 diabetes The aim of this study is to evaluate the association between the frequency and quantity of alcohol intake and the risk of developing CHD among postmenopausal women with diabetesWe conducted a prospective cohort study which included 3198 women with selfreported diabetes and without any history of cardiovascular disease at baseline in the Women’s Health Initiative Observational Study Alcohol intake was assessed by a semiquantitative food frequency questionnaire The primary outcome of this study was CHD which was validated by medical record review Cox proportional hazards regression was used to estimate the hazard ratio HR for the association of alcohol intake and risk of incident CHD while adjusting for several potential confoundersDuring the 22546 personyears of followup there were 336 incident cases of CHD Both frequency and quantity of alcohol intake were inversely associated with the risk of developing CHD Compared to nondrinkers the multivariable HRs across categories of frequency of alcohol consumption ≤05 05–2 and ≥2 drinks/week were 089 95 confidence intervals CI 063 126 084 95 CI 056 125 and 065 95 CI 043 099 respectively p for trend 004 This association did not appear to differ based on the type of the alcoholic beverage consumedModerate alcohol consumption of postmenopausal women with type 2 diabetes may have a benefit on CHD similar to that seen in postmenopausal nondiabetic women The potential risks of alcohol on noncardiac outcomes may need consideration when recommending alcohol to women with diabetesThe Women’s Health Initiative WHI Program is funded by the National Heart Lung and Blood Institute National Institutes of Health US Department of Health and Human Services through contracts N01WH22110 24152 321002 321056 321089 3211113 32115 3211832119 32122 4210726 4212932 and 44221 The study sponsors had no role in the design of the study the collection analysis and interpretation of the data the writing of the manuscript or the decision to submit the manuscript for publication The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health The complete list of WHI centers and investigators can be found online at http//wwwwhiscienceorg/collaborators/investigatorsphp
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