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Title of Journal: Eur J Nutr

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Abbravation: European Journal of Nutrition

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Springer-Verlag

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DOI

10.1007/978-3-211-72464-4_2

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1436-6215

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Modified apple polysaccharide prevents against tum

Authors: Yuhua Li Li Liu Yinbo Niu Juan Feng Yang Sun Xianghe Kong Yongchun Chen Xiaoyan Chen Hongquan Gan Shousong Cao Qibing Mei
Publish Date: 2011/04/24
Volume: 51, Issue: 1, Pages: 107-117
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Abstract

One hundred male ICR mice were administered with 1 2dimethylhydrazine DMH and dextran sodium sulfate DSS Forty mice were given no further treatment the rest were fed basal diet blended with three different doses of MAP 25 5 and 10 20 mice in each groupMAP significantly protected ICR mice against DMH/DSSinduced tumorigenesis The incidence of tumor development was 90 18/20 in the mice treated with DMH/DSS but that was reduced to 25 5/20 15 3/20 and 5 1/20 respectively in the mice treated with basal diets plus 25 5 and 10 of MAP Study of apoptosis of colonic epithelial cells revealed that MAP moderately increased apoptosis suggesting that the antitumor potency of MAP was probably attributed to its ability to induce apoptosis Western blot analysis demonstrated that carbohydratebinding protein galectin3 changed in both the nucleus and the cytoplasm during the process from colitis to colon cancer in the model And MAP could inhibit the binding of galectin3 to its ligand this is at least in part the possible mechanism of MAP by enhancing apoptosis and preventing tumorigenesis

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