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Title of Journal: Eur J Nutr

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Abbravation: European Journal of Nutrition

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Springer Berlin Heidelberg

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DOI

10.1002/aheh.19900180101

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ISSN

1435-1293

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Preventive rather than therapeutic treatment with

Authors: Ana Letícia Malheiros Silveira Adaliene Versiani Matos Ferreira Marina Chaves de Oliveira Milene Alvarenga Rachid Larissa Fonseca da Cunha Sousa Flaviano dos Santos Martins Ana Cristina GomesSantos Angelica Thomaz Vieira Mauro Martins Teixeira
Publish Date: 2015/10/12
Volume: 56, Issue: 1, Pages: 179-191
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Abstract

Inflammatory bowel diseases IBDs are chronic inflammatory disorders with important impact on global health Prebiotic and probiotic strategies are thought to be useful in the context of experimental IBD Here we compared the effects of preventive versus therapeutic treatment with a high fiber diet prebiotic in combination or not with Bifidobacterium longum probiotic in a murine model of chronic colitisAdministration of the high fiber diet protected from acute colitis Protection was optimal when diet was started 20 days prior to DSS A 5day pretreatment with acetate a shortchain fatty acid provided partial protection against acute colitis In chronic colitis pretreatment with the high fiber diet attenuated clinical and inflammatory parameters of disease However when the treatment with the high fiber diet started after disease had been established overall protection was minimal Similarly delayed treatment with acetate or B longum did not provide any protection even when the probiotic was associated with the high fiber dietPreventive use of a high fiber diet or acetate clearly protects mice against acute and chronic damage induced by DSS in mice However protection is lost when therapies are initiated after disease has been established These results suggest that any therapy aimed at modifying the gut environment eg prebiotic or probiotic strategies should be given early in the course of diseaseThis work received financial support from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES Brazil Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq Brazil Fundação de Amparo e Pesquisas do Estado Minas Gerais FAPEMIG Brazil National Institute of Science of Technology in Dengue INCT in Dengue CNPq Brazil We thank Frankcinéia Assis and Ilma Marçal for technical support

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