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Title of Journal: Eur J Nutr

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Abbravation: European Journal of Nutrition

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Springer Berlin Heidelberg

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DOI

10.1016/0005-2744(67)90032-0

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ISSN

1436-6215

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Adaptive response activated by dietary Emphasis T

Authors: Paolo Bergamo Gianna Palmieri Ennio Cocca Ida Ferrandino Marta Gogliettino Antonio Monaco Francesco Maurano Mauro Rossi
Publish Date: 2015/04/04
Volume: 55, Issue: 2, Pages: 729-740
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Abstract

The beneficial effects of conjugated linoleic acid CLA mixture cis9 trans11 c9 trans10 cis12 t10 against gliadininduced toxicity in HLADQ8transgenic mice DQ8 have been associated with improved duodenal cytoprotective mechanisms nuclear factorE2related factor2 Nrf2 acylpeptide hydrolase APEH/proteasome The present study was aimed at investigating the ability of individual CLA isomers to improve the efficacy of these defensive mechanisms and to protect against duodenal injury caused by the combined administration of gliadin and indomethacin GIGlutenmediated enteropathy was induced in DQ8 mice by three intragastric administration of gliadin 20 mg kg−1/bw and indomethacin 15 mg L−1 in drinking water for 10 days GI C9 or t10 CLA 520 mg kg−1/bw/day were orally administered for 2 weeks Prooxidant and toxic effects associated with GI treatment antioxidant/detoxifying ability of c9 or t10CLA and the protective effect induced by c9 pretreatment c9 + GI were evaluated in DQ8 mice duodenum by combining enzymatic immunoblotting histological evaluation and quantitative realtime PCR assaysGI treatment produces the timedependent decline of the considered detoxifying mechanisms thus leading to proapoptotic and prooxidant effects APEH/proteasome pathway was not markedly affected by individual CLA isomers but duodenal redox status and activity/mRNA levels of Nrf2activated enzymes were significantly improved by c9 administration c9 pretreatment protects against GImediated accumulation of oxidative stress markers and histological examination reveals the increase of goblet cells number in mouse duodenum but induces only a partial recovery of APEH/proteasome activity

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