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Title of Journal: Eur J Nutr

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Abbravation: European Journal of Nutrition

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D. Steinkopff-Verlag

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DOI

10.1007/bf00309647

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1436-6215

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Chronic undernutrition alters renal active NaSupe

Authors: João H CostaSilva Paulo A Silva Nadir Pedi Ricardo Luzardo Marcelo EinickerLamas Lucienne S Lara Amélia M Bezerra Carmen CastroChaves Adalberto Vieyra
Publish Date: 2009/05/12
Volume: 48, Issue: 7, Pages: 437-445
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Abstract

Young rats were fed after weaning with a lowprotein and highsalt diet which mimics that used in a vast region of Brazil Body mass was evaluated from weaning up to the 19th week of age Glomerular filtration rate proximal Na+ reabsorption distal Na+ delivery urinary excretion of Na+ and water and urine concentration capacity were evaluated from serum and urine concentrations of creatinine Na+ and Li+ and by measurement of urinary volume and density The Na+ + K+ATPase and the ouabaininsensitive Na+ATPase were studied in vitro by measuring ATP hydrolysis Expression of Na+ + K+ATPase was evaluated by immunodetection with the use of a specific antibody anti α1catalytic subunit isoformUndernourished rats reached early adulthood 14 weeks with body and renal masses that were 23 times lower than controls These rats became hypertensive mean arterial pressure 187 ± 06 kPa vs 155 ± 09 kPa in control group and showed augmented fractional proximal Na+ reabsorption 610 ± 03 vs 818 ± 22 with a concomitant decrease in distal Na+ delivery 95 ± 05 μmol/min vs 140 ± 02 μmol/min per 100 g body weight Urinary Na+ excretion was higher in BRD rats juvenile and adult being however twice the increase in Na+ intake The ATPdependent Na+ transporters were affected in opposite ways The Na+ + K+ATPase activity from undernourished rats fell by 30 in parallel with a 20 decrease in its immunodetection whereas the ouabaininsensitive Na+ATPase which is responsible for the finetune control of Na+ reabsorption increased threefoldThe skillful technical assistance of Glória CostaSarmento José Paulo Soares and Gilsandro J Barbosa da Silva is acknowledged This research was supported by grants from the Brazilian Research Council CNPq the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES the Rio de Janeiro State Research Foundation to Marcelo EinickerLamas and Adalberto Vieyra and the José Bonifácio Foundation to Lucienne S Lara João H CostaSilva and Nadir Pedi were recipients of a fellowship from CNPq Paulo A Silva and Ricardo Luzardo were recipients of a fellowship from CAPES

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