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Title of Journal: Eur J Nutr

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Abbravation: European Journal of Nutrition

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D. Steinkopff-Verlag

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DOI

10.1016/j.ancene.2015.09.004

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1436-6215

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Minimising the population risk of micronutrient de

Authors: Andrew G Renwick Lars O Dragsted Reg J Fletcher Albert Flynn John M Scott Sandra Tuijtelaars T Wildemann
Publish Date: 2008/01/14
Volume: 47, Issue: 1, Pages: 17-25
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Abstract

At the present time the recommended daily intake or allowance RDA and the safe upper level UL of intake of micronutrients are given as single values The recommended daily intake is considered to cover the requirements of 975 of the population while the safe upper level is a value for the whole population These values provide only limited guidance to risk managersA method has been developed recently which models the relationships between intake and risks of either deficiency or excess using an observed incidence for each effect and population distribution characteristics Using this model it is possible to formulate advice to risk managers on the incidence prevalence of adverse effects due to either deficiency or excess at different levels of intake Application of the model to the data used to derive the RDA and UL for selenium shows that it can predict the impact of changes in nutrient intake on the balance between benefit absence of deficiency and risk development of toxicityApplication of the model has illustrated the utility of this approach but highlighted the need for a comprehensive evaluation of the data and a critical appraisal of the validity of the relationships that are analyzed In addition the derived incidences will usually relate to effects with different biological or health impacts so that the final balance between benefit and risk should be developed by a dialogue between the risk assessor and the risk managerThis work was commissioned by the Addition of Nutrients to Food Task Force of the European branch of the International Life Sciences Institute ILSI Europe Industry members of this task force are Ajinomoto Akzo Nobel Functional Chemicals BASF Campina CocaCola European Union Group DSM Friesland Foods GlaxoSmithKline Groupe Danone Kellogg Kraft Foods Nestlé PepsiCo International Redbull and Unilever For further information about ILSI Europe please call +3227710014 or email infoilsieuropebe The opinions expressed herein are those of the authors and do not necessarily represent the views of ILSI Europe

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