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Title of Journal: Eur J Nutr

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Abbravation: European Journal of Nutrition

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Springer-Verlag

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DOI

10.1002/jmor.1051980205

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1436-6215

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Plasma homocysteine level and hepatic sulfur amino

Authors: Kang Uk Yun Chang Seon Ryu Jung Min Oh Chung Hyun Kim Kye Sook Lee ChulHo Lee HyunSun Lee BongHee Kim Sang Kyum Kim
Publish Date: 2012/01/01
Volume: 52, Issue: 1, Pages: 127-134
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Abstract

Obesity a feature of metabolic syndrome is a risk factor for cardiovascular disease and elevated plasma homocysteine is associated with increased cardiovascular risk However little published information is available concerning the effect of obesity on homocysteine metabolismHighfat diet increased plasma homocysteine but decreased hepatic homocysteine levels Hepatic Sadenosylhomocysteine hydrolase levels were downregulated in the obese mice which was in part responsible for the decrease in hepatic Sadenosylmethionine/Sadenosylhomocysteine which served as an index of transmethylation potential Despite the decrease in hepatic cysteine hepatic taurine synthesis was activated via upregulation of cysteine dioxygenase Hepatic levels of methionine adenosyltransferase I/III methionine synthase methylene tetrahydrofolate reductase and gammaglutamylcysteine ligase catalytic subunit were unchanged Obese mice showed elevated betainehomocysteine methyltransferase and decreased cystathionine betasynthase activities although the quantities of these enzymes were unchangedThis work was supported by the Basic Science Research Program 20090076058 20100007554 and by the Priority Research Centers Program 20090093815 through a Research Foundation of Korea NRF grant funded by the Ministry of Education Science and Technology

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