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Title of Journal: Eur J Nutr

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Abbravation: European Journal of Nutrition

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Steinkopff-Verlag

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DOI

10.1007/bf02449166

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1436-6215

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Lycopene enhances UVA–induced DNA damage and expr

Authors: SL Yeh ML Hu CS Huang
Publish Date: 2004/11/18
Volume: 44, Issue: 6, Pages: 365-370
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Abstract

We examined whether lycopene inhibits ultraviolet A UVA–induced DNA damage and the expression of heme oxygenase–1 HO–1 We hypothesized that the breakdown of lycopene by UVA irradiation rather than intact lycopene itself causes oxidative damageMouse fibroblasts C3H10T1/2 C3H were first enriched with 10 µM of lycopene in the dark for 2 h before exposure to UVA 225 KJ/m2 Then DNA damage measured by the single–cell gel electrophoretic assay comet assay and the expression of HO–1 measured by western blotting were determined In addition we exposed lycopene powder to UVA 225 KJ/m2 to prepare pre–irradiated lycopene ILP Then C3H cells were incubated with ILP for 2 h and DNA damage and the expression of HO–1 also were determinedWe found that lycopene enrichment did not cause damage to DNA in C3H cells not irradiated with UVA However lycopene enrichment strongly induced DNA damage when cells were irradiated with UVA by ca 2–fold as compared to control In addition lycopene enhanced UVA–induced HO–1 expression by ca 25–fold UVA irradiation led to a significant loss of lycopene that had been pre–incorporated into C3H cells When cells were incubated with lycopene that had been pre–irradiated with UVA without subjecting the cells to further UVA irradiation cellular DNA damage and expression of HO–1 were markedly increased and these effects of irradiated lycopene were concentration–dependent

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