Authors: Eva M Persson AnnSofie Gustafsson Anders S Carlsson Ralf G Nilsson Lars Knutson Patrick Forsell Gunilla Hanisch Hans Lennernäs Bertil Abrahamsson
Publish Date: 2005/10/30
Volume: 22, Issue: 12, Pages: 2141-2151
Abstract
Dissolution rate obtained via the rotating disk method and saturation solubility studies were carried out in fed and fasted state HIF fed dog DIF and simulated FeSSIF intestinal fluid for six aprotic low solubility drugs The intestinal fluids were characterized with respect to physical–chemical characteristics and contentsFed HIF provided a 35 to 30times higher solubility compared to fasted HIF and FeSSIF whereas fed DIF corresponded well difference of less than 30 to fed HIF The increased solubility of food could mainly be attributed to dietary lipids and bile acids The dissolution rate was also 2 to 7 times higher in fed HIF than fasted HIF This was well predicted by both DIF and FeSSIF difference of less than 30Intestinal solubility is higher in fed state compared to fasted state However the dissolution rate does not increase to the same extent Dog seems to be a good model for man with respect to dissolution in the small intestine after intake of a meal whereas FeSSIF is a poorer means of determining intestinal saturation solubility in the fed state
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