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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1007/bf01467580

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1573-904X

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A Novel Method for Determining the Solubility of S

Authors: Hala M Fadda Xin Chen Aktham Aburub Dinesh Mishra Rodolfo Pinal
Publish Date: 2014/02/20
Volume: 31, Issue: 7, Pages: 1735-1743
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Abstract

Dissolution end point was clearly ascertained when heat generation stopped The heat of solution was a linear function of dissolved mass for all drugs 10 RSD except for chlorpropamide Heats of solution of 98 ± 08 288 ± 06 457 ± 16 and 1598 ± 201 J/g were obtained for griseofulvin ritonavir prednisolone and chlorpropamide respectively Saturation was identifiable by a plateau in the heat signal and the crossing of the two linear segments corresponds to the solubility limit The solubilities of prednisolone and chlopropamide in water by the calorimetric method were 023 and 0158 mg/mL respectively in agreement with the shakeflask/HPLCUV determined values of 0212 ± 0013 and 0169 ± 0015 mg/mL respectively For the higher solubility and high viscosity systems of griseofulvin and ritonavir in NEP/PVP mixtures respectively solubility values of 65 and 594 mg/g respectively were obtainedSolution calorimetry offers a reliable method for measuring drug solubility in organic and aqueous solvents The approach is complementary to the traditional shakeflask method providing information on the solid properties of the solute For highly viscous solutions the calorimetric approach is advantageousThe authors thank Drs Aziz Bakri and Nawel Khalef from Joseph Fourier University in Grenoble France and Dr Nathan Hesse from TA Instruments for their help and support with the solution calorimeter The Dane O Kildsig Center for Pharmaceutical Processing Research CPPR

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