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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Kluwer Academic Publishers-Plenum Publishers

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DOI

10.1007/s11232-009-0084-5

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1573-904X

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The Relation Between Granule Size Granule Stickin

Authors: A M Bouwman M J Henstra J J M E Hegge Z Zhang A Ingram J P K Seville H W Frijlink
Publish Date: 2005/02/24
Volume: 22, Issue: 2, Pages: 270-275
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Abstract

The torquegranule size relationship could not be explained by the rise in mass of the individual granules it occurs rather through an increase in stickiness of the granules when the moisture content is increased Obviously the increased stickiness that causes the granules to grow also increases the torque Increased stickiness was shown to be the result of an increased deformability of the granules at higher moisture contents in combination with a change in surface properties The elasticplastic behavior ratio of elastic to plastic deformation was found to change at increasing moisture contentsOur results imply that changes in the stickiness of the granular material that may be caused by changes in composition shift the torquesize relationship This may be of particular importance when for example granulation results from placebo batches are used to predict the granule size of drugcontaining batches

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