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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1007/bf00403093

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1573-904X

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Application of Dissolution/Permeation System for E

Authors: Makoto Kataoka Kiyohiko Sugano Claudia da Costa Mathews Jing Wen Wong Kelly Lane Jones Yoshie Masaoka Shinji Sakuma Shinji Yamashita
Publish Date: 2011/12/02
Volume: 29, Issue: 6, Pages: 1485-1494
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Abstract

This D/P system consisting of apical and basal chambers and a Caco2 cell monolayer mounted between chambers can be used to perform simultaneous analysis of drug dissolution and permeation process of drugs applied as various dosage forms Oral administration study with rats was also performed for both drugs as the same dosage formsWhen danazol a lowsoluble and highpermeable drug was applied to the D/P system as various formulations dissolved and permeated amounts were significantly high compared with those from a suspension form On the other hand whereas the dissolved amount of pranlukast a lowsoluble and lowpermeable drug was significantly increased by formulations there were no significant changes observed in the permeated amount between suspension and formulation The oral availability of danazol was significantly increased by formulations but not pranlukast which corresponded well to in vitro evaluations

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