Authors: Tarja Toropainen Teemu Heikkilä Jukka Leppänen Laura Matilainen Sitaram Velaga Pekka Jarho Johan Carlfors VesaPekka Lehto Tomi Järvinen Kristiina Järvinen
Publish Date: 2007/03/24
Volume: 24, Issue: 6, Pages: 1058-1066
Abstract
γCD solution 10 mg/ml in 50 ethanol was pumped together with supercritical carbon dioxide through a coaxial nozzle with or without a model drug budesonide 33 mg/ml The processing conditions were 100 b and 40 60 or 80°C γCD powders were characterised before and after vacuumdrying 2–3 days at RT with XRPD SEM and NMR Budesonide/γCD complexation was confirmed with DSC and XRPD The dissolution behaviour of complexed budesonide was determined in aqueous solution 1 γCD 37°C 100 rpmDuring the SEDS process 100 b 40 and 60°C γCD and budesonide/γCD complexes crystallized in a tetragonal channeltype form The vacuumdrying transformed crystalline γCD into amorphous form while the complexes underwent a tetragonaltohexagonal phase transition The increase in the processing temperature decreased the crystallinity of γCD At 80°C amorphous γCD was obtained while the complexes crystallized in a hexagonal channeltype form The dissolution behaviour of budesonide/γCD complexes was dependent on their crystal structure the tetragonal form dissolved faster than the hexagonal formThis study was financially supported by the Finnish Funding Agency for Technology and Innovation Tekes and the Association of Finnish Pharmacies The authors are grateful to Lab Pharma Ltd Turku Finland for supplying micronized budesonide Mrs Helly Rissanen and Ms Anne Riekkinen are acknowledged for their skillful technical assistance
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