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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1002/cncy.21561

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1573-904X

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Pegylated Nanocapsules Produced by an Organic Solv

Authors: Arnaud Béduneau Patrick Saulnier Nicolas Anton François Hindré Catherine Passirani Holisoa Rajerison Nicolas Noiret JeanPierre Benoit
Publish Date: 2006/08/09
Volume: 23, Issue: 9, Pages: 2190-2199
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Abstract

Nanocapsules covered by PEG1500 stearate were obtained by a low energy emulsification method Conductivity measurements and ternary diagram were performed to describe the formulation mechanism Hemolytic dosage CH50 and pharmacokinetic study in rats have been achieved in order to study the stealth properties of nanocapsulesTransition from an O/W emulsion to a w/O/W emulsion was necessary to produce PEG1500 stearate nanocapsules Interestingly nanocapsules with a size around 26 nm and a polydispersity index inferior to 01 were obtained The CH50 test has revealed a very weak complement consumption in the presence of such nanocapsules Moreover after intravenous injection into rats PEG1500 stearate nanocapsules exhibited long circulating properties The experimental data support the concept of steric repulsion of the surface towards proteins displayed by nanocapsules covered with PEG1500 stearate These in vivo results were in agreement with the PEG1500 density calculated at the nanocarrier surfaceThe authors thank O Lambert for CryoTEM studies UMRCNRS 5471 Bordeaux F−33405 France Université de Bordeaux 1 Bordeaux F33405 France We also want to thank Andréanne Bouchard University of Technology Delft NL2600 AA The Netherlands for her valuable comments and suggestions This work was supported by the departmental committee of MaineetLoire of “Ligue contre le cancer”

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