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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1002/cyto.990070616

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1573-904X

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Microstructure of Tablet—Pharmaceutical Significan

Authors: Changquan Calvin Sun
Publish Date: 2016/07/05
Volume: 34, Issue: 5, Pages: 918-928
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Abstract

The main topics reviewed here include 1 influence of material properties and manufacturing process parameters on the evolution of tablet microstructure 2 impact of tablet structure on tablet properties 3 assessment of tablet microstructure 4 development and engineering of tablet microstructureMicrostructure plays a decisive role on important pharmaceutical properties of a tablet such as disintegration drug release and mechanical strength Useful information on mechanical properties of a powder can be obtained from analyzing tablet porosity—pressure data When helium pycnometry fails to accurately measure true density of a watercontaining powder nonlinear regression of tablet density—pressure data is a useful alternative method A component that is more uniformly distributed in a tablet generally exerts more influence on the overall tablet propertiesDuring formulation development it is highly recommended to examine the relationship between any property of interest and tablet porosity when possible Tablet microstructure can be engineered by judicious selection of formulation composition including the use of the optimum solid form of the drug and appropriate type and amount of excipients and controlling manufacturing process

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