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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1007/s00484-009-0291-7

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ISSN

1573-904X

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Micellar Delivery of Bicalutamide and Embelin for

Authors: Michael Danquah Feng Li Charles B Duke Duane D Miller Ram I Mahato
Publish Date: 2009/05/05
Volume: 26, Issue: 9, Pages: 2081-
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Abstract

Cell viability was determined by MTT assay Micelles were fabricated with polyethylene glycolbpolylactic acid PEGPLA copolymer and characterized in terms of particle size micellar solubilization and drug loading followed by evaluation in nude mice bearing LNCaP xenograftsEmbelin induced caspase 3 and 9 activation in LNCaP and C4–2 cells by decreasing XIAP expression and was more potent than bicalutamide in killing prostate tumor cells irrespective of their androgen status As analyzed by isobologram analysis the combination of bicalutamide and embelin was synergistic for C4–2 but additive and slightly antagonistic for LNCaP cells Micellar formulation resulted in at least 60fold increase in the aqueous solubility of bicalutamide and embelin Tumor growth was effectively regressed upon treatment with bicalutamide but the extent of tumor regression was significantly higher when bicalutamide was formulated in micelles However tumor response to bicalutamide stopped after prolonged treatment and began to grow Sequential treatment with XIAP inhibitor embelin resulted in regression of these hormone refractory tumors

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