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Title of Journal: Pharm Res

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Abbravation: Pharmaceutical Research

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Springer US

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DOI

10.1016/0041-624x(71)90429-x

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1573-904X

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Exploring the Wnt PathwayAssociated LncRNAs and G

Authors: Qi Wang He Jiang Chen Ping Ruizhe Shen Tingting Liu Juanjuan Li Yuting Qian Yanping Tang Shidan Cheng Weiyan Yao Lifu Wang
Publish Date: 2014/01/28
Volume: 32, Issue: 3, Pages: 793-805
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Abstract

We explored lncRNAs profilings in PanIN cell line SHPAN isolated from Pdx1Cre LSLKras G12D/+ mice and PDAC cell line DTPCa isolated from Pdx1Cre LSL Kras G12D/+ LSL Tp53 R172H/+ mice by lncRNAs microarray and detected expression of lncRNAs and genes in PDAC by Realtime PCR Western blot ChIP and immunohistochemistryEight lncRNAs and five proteincoding genes associated with Wnt pathway were identified with more than fivefold changes between DTPCa cells and SHPAN cells Of them lincRNA1611 and Ppp3ca were validated significantly high expression in DTPCa cells and in 22 of 26 fresh resected human PDAC tissues compared to SHPAN cells and normal pancreatic tissues respectively Moreover Tp53 mutation status displayed a positive correlation with lincRNA1611 or Ppp3ca level Immunohistochemical staining for Ppp3ca was weak or lack in 91 of 107 normal pancreatic tissues 24 of 29 PanINI and 13 of 16 PanINII tissues however was strong in 10 of 27 PanINIII and 62 of 107 PDAC tissues post operation

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